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Scientist, Cryo-EM
Company: Johnson & Johnson
Location: Spring House, PA
Employment Type: Full Time
Date Posted: 04/16/2022
Expire Date: 10/05/2022
Job Categories: Biotechnology and Pharmaceutical, Computers, Software, Finance/Economics, Healthcare, Practitioner and Technician, Information Technology, Science, Publishing, Research & Development, Medical
Job Description
Scientist, Cryo-EM

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, Cryo-EM, located in Spring House, PA.


At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.


Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information.


The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad disciplines including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding and motivated individual to join our team as Scientist, Cryo-EM.


Key Responsibilities:

  • Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for small/large molecule agent optimization.
  • Be responsible for preparing the EM grids, maintaining the Glacios microscope, and determination of high-resolution structures by Cryo-EM and communicating these results to the project teams.
  • Explore updated sample preparation technique and data-collection strategies.
  • Work closely with protein scientists, biophysicists, protein NMR and X-Ray crystallography scientists as part of an integrated structural biology effort.
  • Contribute to increase the structural biology scientific expertise of the group by publishing high-impact research papers, attending and presenting at scientific conferences, internalizing impactful outside technologies and techniques, and establishing academic collaborations.
  • Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.



  • Ph.D. or equivalent and postdoctoral experience in structural biology (Cryo-EM, X-Ray crystallography, biophysics, protein engineering) or related field is required.


Experience and Skills:


  • Deep scientific expertise in structural biology, with strong experience in sample preparation using Vitrobot, data collection via EPU and structure determination are required.
  • Expertise with Cryo-EM software packages (Relion/cisTEM/CryoSPARC) in a mixed Linux/Windows computational environment are required.



  • Knowledge of protein production techniques and protein stability requirements is preferred.
  • Experience in Micro-ED or Cryo-tomography is preferred.
  • Experience in machine learning is preferred.
  • Experience in structure-guided small/large molecule design, and vaccine antigen design utilizing Cryo-EM are preferred.
  • Broad knowledge of biophysics (such as ITC, DSF, SPR, ASMS, HDX-MS), biochemistry, molecular pharmacology, and protein sciences is preferred.
  • Research experience in X-Ray crystallography, protein NMR or orthogonal structural biology technologies is preferred.
  • Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred.



  • Strong record of external publications and presentations is required.
  • Outstanding written and oral communication skills are required.
  • Up 10% travel may be required.


At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.

Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC (6084)
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