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Q&A With Mariano Severgnini

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Mariano Severgnini
Independent Consultant, BoudiccaDX

Location: Burlington, MA United States
Joined: Jul 13th, 2023
About   (request update)
Education   (request update)
- College Not Listed - class of 1999
Undergrad Major: Biology
Experience
I currently work with BoudiccaDX as Independent Consultant
I have years of experience working in the Biotechnology and Pharmaceutical industry.
Independent Consultant Clinical Biomarkers and Companion Diagnostics | BoudiccaDx, LLC
From January 2024 to Current • 2 year(s)
Reviews biomarker content in clinical trial documents and supports clients with biomarker identification, companion diagnostic development, and translational research strategy.
Sr Director Clinical Biomarkers/Companion Diagnostics, Clinical and Translational Sciences Department | Curis, Inc
From January 2022 to December 2024 • 2 year(s)
Developed clinical biomarker strategies for IRAK4/FLT3 inhibitor and anti-VISTA programs across multiple Phase I and II clinical trials, leading cross-functional teams for translational strategy development.
Lead Scientist/Director, Medical Oncology/Center for Immuno-Oncology | Dana-Farber Cancer Institute / Harvard Medical School
From January 2014 to December 2022 • 8 year(s)
Directed the CIO-Immune Assessment Lab, managed up to 15 lab members, and led translational research efforts for over 80 clinical trials in immuno-oncology.
Scientist I, Drug Discovery Group | RaNA Therapeutics, LLC
From January 2012 to December 2014 • 2 year(s)
Developed in vitro and in vivo models for oligonucleotide drug screening targeting rare and autoimmune diseases, led Drug Discovery Group scientific strategy.
Sr/Principal Research Associate-Senior Research Associate, Drug Delivery Team | Alnylam Pharmaceuticals, Inc
From January 2008 to December 2012 • 4 year(s)
Performed testing of siRNA-GalNAC conjugates and LNPs in primary cells and in vivo models, developed assays for delivery, efficacy and immune toxicity testing.
Research Fellow, Pulmonary and Critical Care Division | New England Medical Center/Tufts University Medical School
From January 2001 to December 2008 • 7 year(s)
Led technical activities for NIH and pharmaceutical company grants, developed animal models of pulmonary inflammation and studied JAK/STAT pathway in asthma.
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